抽象的
Severe Dynamic Hyperinflation during Mechanical Ventilation in Asthma and COPD; The Role of Neurally Adjusted Ventilatory Assist (NAVA)
Emiel Boon
Dynamic hyperinflation is a well known phenomenon in chronic obstructive pulmonary disease (COPD). It depends on expiratory airflow resistance and expiratory time. During exercise there is a gradual increase of the functional residual capacity (FRC) and end expiratory lung volume (EELV) while there is a decrease of inspiratory capacity (IC). From the Campbell diagram can be depicted that the work of breathing will be increased, so limiting exercise capacity. In this lecture clinical cases will be discussed with complicated mechanical ventilation in patients with status astmaticus and acute exacerbation of COPD. Special attention will be paid to the problem of maltriggering during support ventilation. In this situation NAVA may help to overcome the problem of auto-PEEP, in which the neuromuscular output (EdI) is directly derived from the phrenic nerve. Patient ventilator synchrony can so be restored. NAVA can be used wether in invasively ventilated patients as a support mode, or in case of non-invasive ventilation ( NIV-NAVA). The Edi signal can be helpful in revealing exhaustion during weaning or can be diagnostic in neuromuscular disease.
Literature:
1. Ferguson T (2006.) Why does the lung hyper inflate? Proc Am Thorac Soc Vol 3. pp 176–179, 2006.
2. Rochwerg B, Brochard L, Elliott MW, et al. (2017); Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure.. Eur Respir J 50:1602426.
3. Coisel Y, Chanues G, Jung B et.al. (2010) Neurally adjusted ventilator assist in critically ill postoperative patients: A crossover randomized study. Anesthesiology, 113:925-35
4. Roze H, Lafrikh A, Perrier V et.al. (2011) Daily titration of neurally adjusted ventilatory assist using the diaphragm electrical activity. Intensive Care Med 37:1087-1094
5. Piquilloud L, Vignaux L, Bialis E, et.al. (2011) Neurally adjusted ventilatory assist improves patient-ventilator interaction. Intensive Care Med 37:263-271