抽象的

Potential methodologies of intervention for compounds that modify endocrine hormones

Mark Augustine*

The term "endocrine-disrupting chemicals” refers to substances that mimic or inhibit the transcriptional activation caused by naturally occurring steroid hormones by attaching to steroid hormone receptors. edc are substances that, according to the food quality protection act of 1996, "may have an impact in humans that is analogous to an effect generated by a naturally occurring oestrogen, or other such endocrine action as the administrator may designate." later, those that act on the oestrogen, androgen, and thyroid hormone receptors were included to the criteria. Through the inhibition of histone deacetylase activity and the stimulation of mitogen-activated protein kinase activity, xenobiotics and environmental pollutants can serve as hormone sensitizers. On DNA methylation state, some endocrine disruptors may have genome-wide impacts.