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Neuroplasticity and drug-seeking behavior: Mechanisms and therapeutic targets.

Christopher Kalivas*

Drug addiction is a complex and chronic disorder characterized by compulsive drug-seeking behavior despite adverse consequences. The persistence of drug-seeking behavior is believed to arise from maladaptive changes in the brain's neural circuitry, particularly in regions involved in reward, motivation, and decision-making. Neuroplasticity, the brain's ability to reorganize and modify its structure and function in response to experience, plays a pivotal role in the development and maintenance of drug addiction.