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Clinical and seroepidemiological description and observations of pure red cell aplasia secondary to parvovirus B19 infection in HIV -positive patients in a third hospital level in Colombia.

Larry Luber Martinez Rosado, Leidy Carolina Rico

Parvovirus B19 is a global infection that can cause serious and life threatening disorders in susceptible patient groups. Viruses of the family Parvoviridae (Latin parvum [meaning small or tiny]), are among the smallest viruses described, 18?28 nm in diameter. There are 2 subfamilies of the family Parvoviridae and Densovirina (Latin denso [thick or compact]). Parvovirinae may infect humans,but Densovirina infect only arthropods. Structurally, these viruses are non-enveloped, icosahedral viruses that contain a single-stranded linear DNA genome. The small size of these viruses mightaccount for their late discovery. In 1974, the first pathogenic human parvovirus was discovered and named B19 from the coding of a serum sample, number 19 in panel B, which gave anomalous results during testing for hepatitis B. Parvovirus B19, genotype 1, has a worldwide distribution. Genotypes 2 and 3 tend to be found in Europe and Africa. We present the clinical and seroepidemiological description of cases of aplasia of the red serie without affecting hematimetric indices in HIV positive patients with positive serology to Parvovirus B19 admitted to the hospitalization service in the period from April 2016 to April 2017.