抽象的

Association of interleukin-4 receptor I75V, Q576R and S503P polymorphisms and haplotypes with risk of allergic rhinitis in a population of China

Jianrong Zhang, Yanfang Huang, Ping Wang, Jing Zhao, Qingping Huang

Objective: We carried out a study to investigate the association of IL-4R I75V (rs1805010), Q576R (rs1801275) and S503P (rs1805015) polymorphisms with the development of AR in a Chinese population.

Methods: Between October 2012 and May 2015, 326 patients with AR and 412 healthy control participants were recruited. IL-4R I75V (rs1805010), Q576R (rs1801275) and S503P (rs1805015) were amplified and genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism method. Multivariate unconditional logistic regression analysis was employed to evaluate the association between IL-4R I75V (rs1805010), Q576R (rs1801275) and S503P (rs1805015) polymorphisms and AR risk.

Results: This study included 184 females and 142 males in AR patients, and 209 females and 203 males in controls. The mean ages of AR patients and controls were 35.82 ± 11.24 and 37.22 ± 12.07 y, respectively. We observed that the GG genotype of IL-4R Q576R (rs1801275) was associated with a reduced risk of AR when compared with the AA genotype of Q576R (rs1801275) (OR=0.43, 95% CI=0.26-0.71, P=0.001). A significant linkage disequilibrium was found between rs1805010 and rs1801275 (D=0.79, r2=0.02). The G-A-T (OR=0.32, 95% CI=0.24-0.42) and G-G-T (OR=0.18, 95% CI=0.12-0.27) haplotypes showed a decreased risk of AR, while the A-A-T revealed an increased risk (OR=4.07, 95% CI=3.25-5.09).

Conclusion: Our study suggests that the IL-4R Q576R (rs1801275) genetic polymorphism is associated with the development of AR, and the G-A-T, G-G-T and A-A-T haplotypes contribute to the susceptibility to AR. The nurses and doctors would provide health education to these high risk individuals.