抽象的

Associated factors in oral clefts in Sistan and Baluchestan province, Iran: A cross sectional study.

Alireza Teimouri, Noor Mohammad Noori

Introduction: Oral Clefts are gaps in upper lip; palate or both that are associated with many factors. The objective of the current study was to evaluate the parental and newborn factors associated with different types of OC in newborns in Zahedan, Iran. Methods: This cross-sectional study performed on 212 oral cleft patients to determine the associated factors. The probable factors related to the patients such as gender, parity and weight and maternal factors such as smoking, family marriage, family history of clefts, maternal age at birth, folic acid taking and etc. were considered. The study was a part of a thesis for degree of doctor of dental surgery (DDS) numbered 6831. The collected data analyzed by SPSS 16 using P-value less than 0.05 as statistically significant. Results: Of patients, 50.5% were female. The prevalence’s of CHDs in OCs were 26.4% and distributed in CL, CP and CLP of 26.8%, 30.4% and 42.9%, respectively. 31.60%, 36.3%, 44.8%, 20.3% and 47.2% of OCs children had family history of OCs, family marriage, maternal fever, tobacco using and taking folic acid during pregnancy, respectively. Weight was significantly in three types of OCs (F=9.795, p<0.001). Children with CLP had the highest birth order significantly (F=18.561, p<0.001). Maternal age at birth was difference in OCs children (F=33.389, p<0.001). CHD distributed uniformly among all types of OCs with the prevalence of 26.8%, 30.4% and 42.9% in CL, CP and CLP respectively (p>0.05). Lack of consuming folic acid (p=0.002), positive family history of OCS (P<0.001), family marriage (p=0.034) were significant. Conclusion: Concluded that most of the maternal features such as fever, smoking, taking folic acid had positive impacts on having OCs children.