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Anti-Hyperglycemic Effects of Aqueous Extracts of Moringa Oleifera in Streptozotocin-Induced Diabetes Wistar Rats

Rakhi Das

In this work, streptozotocin-induced diabetes in Wister rats was compared to the antidiabetic effects of Moringa olifera. We used 16 Wistar rats for the experiment. By chance, there were four groups of four animals each (n=4). Streptozotocin, dissolved in citrate buffer, at a dosage of 70 mg/kg body weight, was administered intraperitoneally to animals in groups 2 and 3 in order to induce diabetes (0.1 m, pH 4.5). Moringa oleifera leaf extract was administered to the animals in groups 2 and 4, respectively. When the study's time was up, the animals were put to death, and the pancreas was taken out, weighed, and homogenized before being tested for the presence of insulin, malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) using the proper diagnostic kits. The results showed that after one week 79% of the rats in the diabetic groups treated with moringa leaves after therapy turned out to be normoglycemic. Moringa's average body weight increased by 18.5% in the third week, 26.5% in the sixth week, and 20.5% in the seventh. After getting treatment for hyperglycemia with moringa, insulin levels nearly returned to normal while pancreatic SOD and GSH concentrations increased in the groups that received the extract. In light of this, it can be said that moringa possesses hypoglycemic properties that can be highly beneficial in the management of diabeties.