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Anti-Diabetic Drugs & Challenge of Cancer Risk

Dr. Eman Ibrahim Anwar

Diabetes has been recognized as a key factor contributing to the development of solid organ malignancies [2]. The strongest cancer association to type-2 DM in both sexes involves those of the liver and pancreas, creating a risk dilemma [2,7]. Descriptive clinical studies confirmed the increased prevalence of hepatocellular carcinoma (HCC) in patients with diabetes, as well as, an increased prevalence of diabetes in patients with HCC [8]. In Egypt, HCC is the second most common cancer in men and the 6th most common cancers in women. Since, approximately 80% of HCCs develop in cirrhotic livers, a rising incidence had been reported in Egypt mostly due to high prevalence of viral hepatitis and its complications. However, this incidence is boosted by the emerging association between DM, cirrhosis and HCC; as according to WHO statistics in 2008, it was estimated that 7.4% of Egyptian females and 7% of Egyptian males above the age of 25 years have elevated blood glucose. Increasing evidences of cancer development in diabetic patients were reported. ?