抽象的

Analysis on risk factors of recurrence and metastasis of breast cancer after breast-conserving surgery for patients with breast cancer

Hai-Ping Xia, Shao-Rong Gao, Xin-Feng Zhang, Fu-Xin Zhou, Chang-Jiang Liu, Song Chen, Wei Ren, Tao Ma, Zi-Yong Liu

Objective: This study aimed to analyse the risk factors of the recurrence and metastasis of breast cancer after breast-conserving surgery.

Methods: There were 102 breast cancer patients who underwent breast surgery reservations in 404 Hospital of the Chinese People’s Liberation Army from January 2011 to December 2014. We had recorded these cases’ 5-y recurrence rate and transfer rate after 1-5 y follow-up and retrospectively analysed the clinical data (including age, tumor size, margin status, receptor status and lymph node metastasis, etc.). The aim of this study was to analyse and summarize the risk factors for breast cancer patients who underwent tumor recurrence and metastasis after breast surgery.

Results: The patients were followed up for one to five years. Their 5-y recurrence rate was 10.78% and the transfer rate was 8.82%. According to Cox proportional hazards regression model, breast cancer breast tumor recurrence risk factors include: tumor volume>2 cm, margin invasion positive, HER-2 receptor-positive, estrogen receptor-positive, lymph node metastasis and tumor stage III (HR=3.7, 5.3, 3.8, 5.5, 5.3, 3.7). Tumor metastasis risk factors include: tumor volume>2 cm, HER-2 receptor-positive, estrogen receptor-positive, lymph node metastasis and tumor stage III (HR=5.3, 3.4, 2.3, 4.6, and 2.9).

Conclusion: Breast cancer patients retained the breast after the tumor volume>2 cm, with cutting edge invasion, HER-2 and estrogen receptor-positive, patients with lymph node metastasis, and stage III is associated with postoperative tumor recurrence. If tumor volume>2 cm, HER-2 and estrogen receptorpositive, patients with lymph node metastasis and stage III are related to tumor metastasis after operation.